Progress in research of Clostridium perfringens toxin.
10.3760/cma.j.cn112338-20220316-00189
- Author:
Hao Ran ZHENG
1
;
Lu Lu BAI
2
;
Yuan Yuan WANG
2
;
Jia Xin ZHONG
2
;
Jin Xing LU
2
;
Hui Ling DENG
3
;
Qun XIE
4
;
Yuan WU
2
Author Information
1. Shaanxi University of Traditional Chinese Medicine, Xi'an 712046, China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
3. Xi'an Central Hospital, Xi'an 710003, China.
4. School of Public Health, Xiangnan University, Chenzhou 423000, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Clostridium perfringens;
Antibodies;
Polymerase Chain Reaction
- From:
Chinese Journal of Epidemiology
2022;43(11):1860-1868
- CountryChina
- Language:Chinese
-
Abstract:
Clostridium perfringens can produce many kinds of toxins and hydrolase, causing gas gangrene, enteritis and enterotoxemia in both human and animals. It is known that C. perfringens can produce more than 20 toxins and hydrolases. The different toxin types are associated with specific disease types. At present, molecular toxin-typing method by PCR has replaced the traditional serological typing method. In this study, we systematically summarize the types, basic characteristics, pathogenic mechanism and the relationship with disease of C. perfringens toxins to provide evidence for the establishment of rapid detection method, immune antigen screening, antibody preparation and research of related pathogenic mechanism.
