Association between mild cognitive impairment and all-cause mortality in elderly population in China: a Meta analysis.
10.3760/cma.j.cn112338-20220207-00096
- VernacularTitle:我国老年人轻度认知障碍与全因死亡关联的Meta分析
- Author:
Zhi Qiang LI
1
;
Sheng Shu WANG
2
;
Xin Ran GONG
1
;
Yan Ding WANG
1
;
Di WU
1
;
Mei Tao YANG
1
;
Jin Peng GUO
3
;
Rui Zhong JIA
3
;
Miao LIU
4
;
Yao HE
2
;
Yong WANG
1
Author Information
1. School of Public Health, China Medical University, Shenyang 110122, China Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing 100071, China.
2. Institute of Geriatrics, Second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Chinese People's Liberation Army General Hospital & Chinese People's Liberation Army Medical Academy, Beijing 100853, China.
3. Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing 100071, China.
4. Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
- Publication Type:Meta-Analysis
- MeSH:
Aged;
China/epidemiology*;
Cognition;
Cognition Disorders;
Cognitive Dysfunction/epidemiology*;
Humans;
Mass Screening
- From:
Chinese Journal of Epidemiology
2022;43(9):1479-1484
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To quantitatively evaluate the association between mild cognitive impairment and all-cause mortality. Methods: The research papers of the association between cognitive impairment and all-cause mortality in the elderly in the databases of PubMed, EMBASE, Wang Fang data and CNKI published as of August 1, 2021 were comprehensively retrieved. Software R 4.02 was used for Meta-analysis. Results: A total of 9 research papers were included, involving 48 709 patients. The quality of included papers was high. The results of Meta-analysis showed that the association between mild cognitive impairment and the increased risk of all-cause mortality was statistically significant. Compared with the normal cognitive population, the risk of mortality in the elderly with mild cognitive impairment increased by 39% (HR=1.39, 95%CI: 1.18-1.63). Conclusions: The current research evidence showed that mild cognitive impairment assessed by MMSE screening scale can be used as an independent predictor of the increased risk of all-cause mortality in the elderly population in China. However, due to the limitation of the number of included studies and sample size, the conclusions need to be supported by more evidence studies.
