Correlation between sleep status and frailty in adults aged 30-79 years in China.
10.3760/cma.j.cn112338-20220110-00018
- VernacularTitle:我国30~79岁成年人中睡眠状况与衰弱的相关性研究
- Author:
Yun Qing ZHU
1
;
Jun Ning FAN
1
;
Can Qing YU
2
;
Jun LYU
2
;
Yu GUO
3
;
Pei PEI
4
;
Qing Mei XIA
4
;
Huai Dong DU
5
;
Yi Ping CHEN
5
;
Jun Shi CHEN
6
;
Zheng Ming CHEN
7
;
Li Ming LI
2
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
3. Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China.
4. Chinese Academy of Medical Sciences, Beijing 100730, China.
5. Medical Research Council Population Health Research Unit at the University of Oxford, Oxford OX3 7LF, UK Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
6. China National Center for Food Safety Risk Assessment, Beijing 100022, China.
7. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
- Publication Type:Journal Article
- MeSH:
Adult;
China/epidemiology*;
Frailty/epidemiology*;
Humans;
Obesity;
Obesity, Abdominal;
Sleep/physiology*;
Sleep Initiation and Maintenance Disorders/epidemiology*;
Sleep Wake Disorders;
Snoring/epidemiology*
- From:
Chinese Journal of Epidemiology
2022;43(9):1349-1356
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation between sleep status and frailty in adults aged 30-79 years in China, and explore the potential effect modification of general and central obesity. Methods: Based on the baseline data of the China Kadoorie Biobank, we used multinomial logistic regression to analyze the correlation between long and short sleep duration, insomnia disorder, snoring, and unhealthy sleep score with risks of pre-frailty and frailty. Both overall and obesity-stratified analyses were performed. Result: Among the 512 724 participants, 2.3% had frailty and 40.1% had pre-frailty. There was a U-shaped relationship between sleep duration and frailty score. Short (OR=1.21, 95%CI: 1.19-1.23) or long sleep duration (OR=1.19, 95%CI: 1.17-1.21), insomnia disorder (OR=2.09, 95%CI: 2.02-2.17), and snoring (OR=1.61, 95%CI: 1.59-1.63) were all positively correlated with pre-frailty, and dose-response relationships were observed between unhealthy sleep score and pre-frailty (P for trend<0.001), with OR values of 1.46 (1.44-1.48), 1.97 (1.93-2.00) and 3.43 (3.21-3.67) respectively for those having unhealthy sleep score of 1 to 3. These sleep problems were also positively correlated with frailty. Compared with the overweight or obesity group, stronger relationships were observed between short sleep duration and frailty or pre-frailty and between insomnia disorder and pre-frailty, while the relationships between snoring and frailty and pre-frailty were weaker in the participants with normal weight (P for interaction <0.007 for all). We also observed similar effect modification by central obesity. Conclusion: Long or short sleep duration, insomnia disorder, snoring and higher unhealthy sleep scores were positively correlated with pre-frailty or frailty, general and central obesity status could modify the relationships.
