Analysis on the sequence mutation and evolution of HBV genome in China.
10.3760/cma.j.cn112338-20220411-00278
- VernacularTitle:中国乙型肝炎病毒基因组序列突变及进化分析
- Author:
Yong Hao GUO
1
;
Qiao Hua DOU
1
;
Qian LIU
1
;
Jian Hua YANG
1
;
Yuan Yu LYU
1
;
Da Xing FENG
1
;
Ming Hua SENG
1
;
Yan Yang ZHANG
1
;
Dong Yang ZHAO
1
Author Information
1. Medicine Key Laboratory of Immunoprophylaxis, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
- Publication Type:Journal Article
- MeSH:
China/epidemiology*;
DNA, Viral/genetics*;
Drug Resistance, Viral/genetics*;
Genome, Viral;
Genotype;
Hepatitis B virus/genetics*;
Humans;
Mutation
- From:
Chinese Journal of Epidemiology
2022;43(8):1309-1314
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand immune escape mutation, drug resistance mutation, and genome evolution information of HBV genome sequence in China. Methods: The whole genome sequence information of HBV in China submitted in GenBank from 1998 to 2021 was selected as the object for analysis. MAFFT method was used for cluster analysis. Analysis of immune escape and drug-resistant mutations was performed using the online tool Gen2pheno. The BEAST 1.10.4 was used for analysis the time evolution of HBV sequences. Results: A total of 5 426 sequences were included in the dataset and distributed in 19 provinces of China. Type C accounted for the highest proportion (59.1%, 3 211/5 426), followed by type B (33.7%, 1 833/5 426). Immune escape mutations were found in 764 sequences (14.1%, 764/5 426). At least one reverse transcriptase region mutation occurred in 98.1% of the sequences. The evolutionary roots of most HBV sequences in China date from around 1801 AD. Conclusion: HBV-resistant mutation rate is high in China. HBV genomes evolve slowly.
