Analysis of respiratory syncytial virus infection in hospitalized children with acute lower respiratory tract infection in China from 2017 to 2020.
10.3760/cma.j.cn112150-20220311-00227
- Author:
Yun ZHU
1
;
Gen LU
2
;
Rong JIN
3
;
Yun SUN
4
;
Yun Xiao SHANG
5
;
Jun Hong AI
1
;
Ran WANG
1
;
Xiang Peng CHEN
1
;
Ya Li DUAN
1
;
Meng ZHANG
1
;
Chang Chong LI
6
;
Baoping XU
7
;
Zhengde XIE
1
Author Information
1. Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing 100045, China.
2. Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
3. Guiyang Maternal and Child Health Care Hospital, Guiyang 550003, China.
4. Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China.
5. Shengjing Hospital of China Medical University, Shenyang 110004, China.
6. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
7. Department of Respiratory Diseases I, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing 100045, China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Male;
Female;
Infant;
Child, Preschool;
Respiratory Syncytial Virus Infections/epidemiology*;
Child, Hospitalized;
Prospective Studies;
Respiratory Tract Infections/epidemiology*;
Respiratory Syncytial Virus, Human;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2022;56(12):1739-1744
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the detection rate, epidemic pattern of respiratory syncytial virus (RSV) in hospitalized children with acute lower respiratory tract infection (ALRTI) in China. Methods: From June 2017 to March 2020, a prospective multi-center study on the viral aetiology among hospitalized children with ALRTI was conducted in six pediatrics hospital of North China, Northeast, Northwest, South China, Southeast, and Southwest China. A total of 2 839 hospitalized children with ALRTI were enrolled, and the respiratory specimens were collected from these cases. A multiplex real-time RT-PCR assay were employed to screen the respiratory viruses, and the molecular epidemiological and clinical characteristics of children infected with RSV were analyzed. Results: The positve rate of RSV was 18.6% (528/2 839), and the positive rate of RSV in different regions ranged from 5.5% to 44.3%. The positive rate of RSV in male was higher than that in female (20.2% vs 16.3%), and there was a significant statistically difference between two groups (χ2=6.74, P=0.009). The positive rate of RSV among children under 5 years old was higher than that among children older than 5 years old (22.3% vs 4.5%), and there was a significant statistically difference between two groups (χ2=97.98,P<0.001). The positive rate of RSV among the <6 months age group was higher than that of other age groups (all P<0.05). During January 2018 and December 2019, RSV was detected in almost all through the year, and showed peaks in winter and spring. RSV-positive cases accounted for 17.0% (46/270) among children with severe pneumonia, including 36 cases infected with RSV alone. Conclusion: RSV is an important viral pathogen in children under 5 years old with ALRTI in China. The virus can be detected almost all through the year and reached the peak in winter and spring. RSV could lead to severe pneumonia in children and caused huge threaten to children's health.
