Advances in the relationship between lung cancer and microbiota.
10.3760/cma.j.cn112150-20220124-00083
- Author:
Yun Hu ZHAO
1
;
Meng Di LU
1
;
Jian Feng LIAO
1
;
Kai Xuan YUAN
1
;
Xin Qiang ZHANG
1
;
Bing GU
1
Author Information
1. Division of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Probiotics;
Prebiotics;
Microbiota;
Lung Neoplasms
- From:
Chinese Journal of Preventive Medicine
2022;56(12):1716-1722
- CountryChina
- Language:Chinese
-
Abstract:
Interaction exists in lung cancer and microbiota. Lung microecological homeostasis can improve the immune tolerance, enhance immune suppression, and inhibit inflammatory responses, to reduce the lung cancer; while lung cancer can lead to pulmonary microecological imbalance, change the lung environment, and promote tumor cell proliferation. Therefore, modulating microbial flora and microecological immunotherapy may be a potential and preventive treatment for lung cancer, to restore tumor immunosuppression and improve patient survival. However, the individual differences in the lung microecology, because of different genetics, ethnic characteristics, and dietary habits, increasing the difficulty of precise diagnosis and treatment, which is also the current bottleneck in the application of microecological immunotherapy. Otherwise, the effectiveness of regulatory measures such as probiotics, prebiotics or antimicrobials is questionable. The research on microbial flora is still in its infancy, and further exploration is needed to form a standardized, effective, and precise treatment plan. So, standardized, effective, and precise microbial flora treatment strategies need to be further explored.
