Association of lead exposure with stunting and underweight among children aged 3-5 years in China.
10.3760/cma.j.cn112150-20211229-01197
- Author:
Zheng LI
1
;
Yao Bin LYU
1
;
Feng ZHAO
1
;
Qi SUN
1
;
Ying Li QU
1
;
Sai Sai JI
1
;
Tian QIU
1
;
Ya Wei LI
1
;
Shi Xun SONG
1
;
Miao ZHANG
1
;
Ying Chun LIU
1
;
Jia Yi CAI
1
;
Hao Can SONG
1
;
Xu Lin ZHENG
2
;
Bing WU
2
;
Dan Dan LI
1
;
Ying LIU
3
;
Ying ZHU
1
;
Zhao Jin CAO
1
;
Xiao Ming SHI
4
Author Information
1. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
2. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
3. School of Public Health, Jilin University, Changchun 130012, China.
4. China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
- Publication Type:Journal Article
- MeSH:
Child;
Female;
Humans;
Infant;
Male;
Lead;
Thinness/epidemiology*;
Growth Disorders/epidemiology*;
Body Height;
Nutritional Status;
Prevalence;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2022;56(11):1597-1603
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the association of lead exposure with stunting and underweight among children aged 3-5 years in China. Methods: Data was collected from China National Human Biomonitoring (CNHBM) between January 2017 and December 2018. A total of 3 554 children aged 3-5 years were included. Demographic characteristic, lifestyle and nutritional status were collected through questionnaires. Height and weight were measured by standardized method. Stunting and underweight status were determined by calculating height for age Z-score and weight for age Z-score. Blood and urine samples were collected to detect the concentrations of blood lead, urinary lead and urinary creatinine. Children were stratified into 4 groups (Q1 to Q4) by quartiles of blood lead level and corrected urinary lead level, respectively. Complex sampling logistic regression models were applied to evaluate the association of the blood lead level, urinary lead level with stunting and underweight. Results: Among 3 554 children, the age was (4.09±1.06) years, of which 1 779 (80.64%) were female and 1 948 (55.84%) were urban residents. The prevalence of stunting and wasting was 7.34% and 2.96%, respectively. The M (Q1, Q3) for blood lead levels and urinary lead levels in children was 17.49 (12.80, 24.71) μg/L, 1.20 (0.61, 2.14) μg/g Cr, respectively. After adjusting for confounding factors, compared with the lowest blood lead concentration group Q1, the risk of stunting gradually increased in the Q3 and Q4 group (Ptrend=0.010), with OR (95%CI) values of 1.40 (0.80-2.46) and 1.80 (1.07-3.04), respectively. Compared with the lowest urinary lead concentration group Q1, the risk of stunting still increased in the Q3 and Q4 group (Ptrend=0.012), with OR (95%CI) values of 1.69 (1.01-2.84) and 1.79 (1.05-3.06), respectively. The correlation between the lead exposure and underweight was not statistically significant (P>0.05). Conclusion: Lead exposure is positively associated with the risk of stunting among children aged 3-5 years in China.
