The applications and challenges of liquid chromatography tandem mass spectrometry in maternal and child health.
10.3760/cma.j.cn112150-20220329-00298
- Author:
Lin LIU
1
;
Zheng Wen XU
1
;
Lan Lan MENG
1
;
Yi Fan LU
1
;
Yan Hong ZHAI
1
;
Zheng CAO
1
Author Information
1. Department of Laboratory Medicine, Center of Clinical Mass Spectrometry, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital,Beijing 100026,China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Chromatography, Liquid/methods*;
Tandem Mass Spectrometry/methods*;
Child Health;
Steroids/analysis*;
Vitamins/analysis*;
Bile Acids and Salts
- From:
Chinese Journal of Preventive Medicine
2022;56(10):1520-1526
- CountryChina
- Language:Chinese
-
Abstract:
Due to its ultra-high sensitivity, specificity and throughput, liquid chromatography tandem mass spectrometry (LC-MS/MS) has become an important analytical tool in clinical laboratories in quantifying various small molecules, such as vitamins, bile acids, steroids and other internal metabolites relevant to maternal diseases. As an effective means of screening and diagnosing diseases in preventive medicine, LC-MS/MS has been widely used in maternal and child health, contributing to the reduction of the incidence of maternal and child diseases and premature morbidity and mortality. At present, LC-MS/MS is an emerging and powerful platform in laboratory testing in China, facing both challenges and opportunities. In this article, the representative applications in the field of maternal and child health are summarized and discussed, along with the major hurdles of LC-MS/MS in clinical recognition and implementation.
