Consideration on the possible etiological mechanisms and countermeasures about severe acute hepatitis of unknown origin in children.
10.3760/cma.j.cn112150-20220603-00572
- Author:
Lei Jie WANG
1
;
Guang Xin YU
1
;
Yu WU
1
;
Xin Yue YANG
1
;
Yuan GAO
2
;
Lin WANG
1
;
Xiang Mei CHEN
1
;
Feng Min LU
3
Author Information
1. Department of Microbiology & Infectious Disease Center/School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
2. The Fourth Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
3. Department of Microbiology & Infectious Disease Center/School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China Hepatology Institute, Beijing Key Laboratory of hepatitis C and Immunotherapy for Liver disease/Peking University People's Hospital, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
United States;
COVID-19;
Disease Outbreaks;
Hepatitis/epidemiology*;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2022;56(10):1499-1504
- CountryChina
- Language:Chinese
-
Abstract:
Since April 2022, severe acute hepatitis of unknown origin in children has spread to 35 countries and regions around the world, and more than 1 010 cases have been reported. Since the severe acute hepatitis of unknown origin involves a wide range of areas and has a high rate, it is critical to identify the etiology and establish effective preventive, diagnostic and therapeutic measures as soon as possible. This study discusses the possible mechanisms and countermeasures of the severe acute hepatitis of unknown origin in children. It speculates that the occurrence of the recent severe acute hepatitis might be related to adenovirus, adeno-associated virus infection, and the COVID-19 epidemic, while the difference in HLA polymorphism among different races might be related to the fact that reported cases were more common in Europe and the United States. Based on the currently available evidence, it can be preliminarily judged that the risk of large-scale outbreak of severe acute hepatitis of unknown origin in children would be low in China, but the persistent awareness and vigilance of the etiology is still needed.
