Antibody levels of measles, rubella and mumps viruses in healthy population in Shanghai from 2010 to 2020.
10.3760/cma.j.cn112150-20211116-01057
- Author:
Yu Ying YANG
1
;
Su Wen TANG
1
;
Wei TANG
1
;
Jia Lei FAN
2
;
Zhi LI
1
;
Jia Wei YANG
1
;
Jia REN
1
;
Chong Shan LI
3
Author Information
1. Department of Pathogen Biological Detection, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
2. Department of Infectious Disease Prevention and Control, Shanghai Minhang District Municipal Center for Disease Control and Prevention, Shanghai 201101, China.
3. Shanghai Institute of Infectious Disease and Biosecurity, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Antibodies, Viral;
Child;
China/epidemiology*;
Female;
Humans;
Immunoglobulin G;
Infant;
Male;
Measles/prevention & control*;
Measles-Mumps-Rubella Vaccine;
Mumps/prevention & control*;
Mumps virus;
Rubella/prevention & control*;
Young Adult
- From:
Chinese Journal of Preventive Medicine
2022;56(8):1095-1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine IgG antibody levels of measles, rubella, mumps in healthy population in Shanghai from 2010 to 2020 and analyze the trend of antibody changes in different age groups. Methods: 10 828 healthy people without measles, rubella and mumps in Shanghai were included in the study from 2010 to 2020. Serum samples were collected from 12 age groups, and the serum IgG antibody of measles, rubella and mumps were detected by ELISA. The difference of antibody positive rates and antibody levels were analyzed. Results: The median age M (Q1, Q3) of 10 828 objects were 8 years old (9 months old, 20 years old). Males accounted for 48.34% (5 234/10 828) and females accounted for 50.92% (5 514/10 828). Unknown gender information accounted for 0.74% (80/10 828), and 27.03% (2 927/10 828) of participants had unknown MMR immunization history. The total positive rates of measles, rubella and mumps IgG antibody were 76.78%, 64.46% and 64.29% and their GMCs were 541.45 mIU/ml, 31.76 IU/ml and 133.73 U/ml respectively. There were significant differences in serum IgG antibody GMC of measles, rubella and mumps in each year (Fmeasles=180.74, P<0.001; Frubella=189.95, P<0.001; Fmumps=122.40, P<0.001). The positive rate of measles antibody was higher than that of rubella and mumps, and the difference was statistically significant (χ²=518.09, P<0.001). Conclusion: The level of measles IgG antibody in healthy people in Shanghai is higher, while the level of rubella and mumps IgG antibody is slightly lower.
