Impact of regional positive lymph node ratio of gallbladder carcinoma on prognosis.
10.3760/cma.j.cn112152-20210612-00446
- Author:
Ye Ming ZHOU
1
;
Hong Chao MI
1
;
Wei JIANG
1
;
Yin JIANG
1
;
Yong Fei HUA
1
;
Chang Jiang LU
1
;
Chun Nian WANG
2
;
Cai De LU
1
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, Ningbo University Affiliated Lihuili Hospital, Ningbo 315000, China.
2. Ningbo Clinical Diagnostic Pathology Center, Ningbo 315000, China.
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Positive lymph node ratio;
Prognosis
- MeSH:
Humans;
Lymph Node Ratio;
Gallbladder Neoplasms/pathology*;
Lymph Node Excision;
Lymphatic Metastasis/pathology*;
Neoplasm Staging;
Retrospective Studies;
Lymph Nodes/pathology*;
Prognosis
- From:
Chinese Journal of Oncology
2022;44(11):1202-1207
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the impact of regional positive lymph node ratio (LNR) on prognosis of patients with gallbladder carcinoma. Methods: The clinicopathological and survival data of 53 patients with gallbladder carcinoma who underwent radical resection with regional lymph node metastasis in Ningbo University Affiliated Lihuili Hospital from May 2012 to December 2020 were collected, and receiver operating characteristic curve (ROC) was used to determine the optimal cut-off value of LNR for predicting postoperative survival status in patients with gallbladder carcinoma. According to the critical value, the patients were divided into low LNR group and high LNR group. The clinicopathological features and prognosis of the two groups were compared. Log rank test was used for univariate analysis of prognostic factors in patients with gallbladder carcinoma, and Cox proportional hazards model was used for multivariate analysis. Results: A total of 417 regional lymph nodes were dissected in 53 patients, of which 144 lymph nodes were positive, with a positive rate of 34.5%. The optimal cut-off value of LNR for predicting postoperative survival status of patients with gallbladder carcinoma was 0.33. According to this cut-off value, patients were divided into low LNR group (LNR≤0.33, 28 cases) and high LNR group (LNR>0.33, 25 cases). The recurrence rates were 64.3% (18/28) and 88.0 % (22/25) in low LNR group and high LNR group, respectively. The median recurrence-free survival (RFS) was 8 and 7 months, respectively (P=0.032). In the low LNR group, the 1-, 3-, and 5-year survival rates were 56.2%, 38.4%, and 32.0%, respectively, and the median overall survival (OS) was 16 months. In the high LNR group, the 1-, 3-, and 5-year survival rates were 37.9%, 5.4%, and 0, respectively, and the median OS was 9 months. The postoperative survival rate of patients in the low LNR group was better than that in the high LNR group (P=0.008). Univariate analysis showed that LNR was even associated with RFS and OS in patients with gallbladder carcinoma (P<0.05). Multivariate analysis showed that LNR>0.33 was an independent risk factor for postoperative RFS (HR=1.977, 95% CI: 1.045-3.740), but not for OS (HR=1.561, 95% CI: 0.685-3.553). Conclusion: On the basis of clearing a sufficient number of regional lymph nodes, patients with gallbladder carcinoma with regional LNR>0.33 are more likely to relapse after operation, but the predictive value of LNR>0.33 OS is insufficient.
