Prevalence and risk factors of coronary artery calcification on lung cancer screening with low-dose CT.
10.3760/cma.j.cn112152-20201114-00986
- Author:
Ze Wei ZHANG
1
;
Yu Jing JIN
1
;
Shi Jun ZHAO
2
;
Li Na ZHOU
2
;
Yao HUANG
2
;
Jian Wei WANG
2
;
Wei TANG
2
;
Ning WU
1
Author Information
1. Department of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021 China.
2. Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Coronary artery;
Low-dose CT;
Lung neoplasms;
Risk factors;
Screening
- MeSH:
Male;
Female;
Humans;
Coronary Artery Disease/epidemiology*;
Early Detection of Cancer;
Prevalence;
Lung Neoplasms/epidemiology*;
Vascular Calcification/epidemiology*;
Risk Factors;
Tomography, X-Ray Computed/methods*;
Hypertension;
Hyperlipidemias
- From:
Chinese Journal of Oncology
2022;44(10):1112-1118
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prevalence and risk factors of coronary artery calcification (CAC) on lung cancer screening with low-dose computed tomography (LDCT). Methods: A total of 4 989 asymptomatic subjects (2 542 males and 2 447 females) who underwent LDCT lung cancer screening were recruited at Cancer Hospital, Chinese Academy of Medical Sciences from 2014 to 2017. The visual scoring method was used to assess coronary artery calcification score. χ(2) test or independent t-test was used to compare the difference of CAC positive rate among different groups. Multivariate logistic regression was used to analyze risk factors associated with CAC in the study. Results: Of the 4 989 asymptomatic subjects, CAC occurred in 1 018 cases. The positive rate was 20.4%, of which mild, moderate and severe calcification accounted for 86.3%, 11.4% and 2.3%, respectively. Gender, age, BMI, education level, occupation, smoking history, diabetes, hypertension and hyperlipidemia had statistically significant differences in CAC positive rates among groups. Multivariate logistic regression analysis showed that gender, age, diabetes, hypertension, hyperlipidemia and smoking history were risk factors for CAC. Age, diabetes, hypertension and smoking history were statistically significant risk factors between the mild and moderate CAC group. A total of 1 730 coronary arteries in 1 018 CAC positive cases had calcification, CAC positive rate of left anterior descending was the highest(51.3%); 568 cases (55.8%) were single vessel calcification, 450 cases (44.2%) were multiple vessel calcification. Conclusions: LDCT can be used for the 'one-stop' early detection of lung cancer and coronary atherosclerosis. Gender, age, diabetes, hypertension, hyperlipidemia and smoking are related risk factors for coronary atherosclerosis.
