Evaluation of left ventricular function with left atrio-ventricular longitudinal strain in patients with lymphoma underwent anthracycline therapy.
10.3760/cma.j.cn112148-20220727-00583
- Author:
Zheng LI
1
;
Qun Ling ZHANG
2
;
Yi Hui SHEN
3
;
Xian Hong SHU
4
;
Lei Lei CHENG
1
Author Information
1. Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China Shanghai Institute of Cardiovascular disease, Shanghai 200032, China Shanghai Institute of Medical Imaging, Shanghai 200032, China National Clinical Research Center for Interventional Medicine, Shanghai 200032, China.
2. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032 China.
3. Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China Shanghai Institute of Cardiovascular disease, Shanghai 200032, China.
4. Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China Shanghai Institute of Cardiovascular disease, Shanghai 200032, China Shanghai Institute of Medical Imaging, Shanghai 200032, China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Male;
Humans;
Anthracyclines/therapeutic use*;
Ventricular Function, Left;
Retrospective Studies;
Heart Ventricles;
Antibiotics, Antineoplastic/adverse effects*;
Polyketides/pharmacology*;
Lymphoma/drug therapy*
- From:
Chinese Journal of Cardiology
2022;50(11):1064-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the value of 3-dimensional speckle tracking echocardiograghy (3D-STE) derived strain parameters on the detection of subclinical myocardial deformation alterations in patients with lymphoma treated with anthracycline agents. Methods: This study was a retrospective study. A total of 37 patients with newly diagnosed diffuse large B cell non-Hodgkin lymphoma between December 2012 and December 2014 in Cancer Center, Fudan university were included. 3D-STE strain measurements were performed at baseline (T0),after the completion of two therapy circles (T1) and at the end of anthracycline regimen chemotherapy (Te). Echocardiography images were analyzed on the TTA workstation, and the indexes included left atrial minimum volume (LAVmin), left atrial emptying index (LAEF), left atrial active emptying index (LAAEF), as well as the left ventricular global longitudinal strain (LVGLS), left ventricular global circumferential strain (LVGCS), left atrial global longitudinal strain (LAGLS). The overall left atrioventricular longitudinal strain (LAVGLS) was calculated, which was the sum of the absolute values of LVGLS and LAGLS. The changes of left ventricular strain indexes measured by 3D-STE at different time points of patients were evaluated. Results: Thirty-seven patients with DLBCL, aged (48.3±12.1)years, including 23 males (63.9%), were enrolled. Compared with baseline, LVGLS (T1: (-18.63±4.73)% vs. (-22.13±4.40)%, P=0.001; Te:(-18.26±4.64)% vs. (-22.13±4.40)%, P<0.001), LAGLS (T1: (20.41±5.56)% vs. (23.98±5.59)%, P=0.003; Te: (17.60±3.96)% vs. (23.98±5.59)%, P<0.001) and LAVGLS (T1: (39.05±7.60)% vs. (46.11±7.77)%, P<0.001; Te: (40.34±8.55)% vs. (46.11±7.77)%, P<0.001) were all deteriorated at the T1 and Te. While LVGCS ((-21.98±5.82)% vs. (-26.15±7.51)%, P=0.010), LAVmin ((23.93±7.29)ml vs. (20.33±7.03)ml, P=0.029), LAEF ((28.94±11.16)% vs. (35.79±11.12)%, P=0.002) and LAAEF ((11.93±10.00)% vs. (18.10±9.96)%, P=0.013) were decreased only until Te. Conclusions: 3D-STE strain measurements could detect early myocaridial function alteration in patients receiving anthracycline regimen chemotherapy, thus may provide a novel approach to monitor anthracycline caused myocardial toxicity.
