Magnesium Sulfate Combined with Monosialoganglioside on Recovery of Motor Function after Spinal Cord Injury in Rats
- VernacularTitle:硫酸镁联合单唾液酸神经节苷脂对脊髓损伤大鼠运动功能恢复的影响
- Author:
Youbo QIU
;
Menglang YUAN
;
Zheng YANG
;
Yu ZHOU
;
Li XI
;
Yao ZHANG
;
Yang CHEN
;
DU GONG
;
Lijun ZHOU
;
Xiao ZHANG
- Publication Type:Journal Article
- Keywords:
monosialoganglioside, magnesium sulfate, spinal cord injury, motor function, malongldialdehyde
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(2):137-140
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of magnesium sulfate combined with monosialoganglioside on the recovery of motor function after spinal cord injury in rats.Methods48 healthy adult rats were randomly divided into groups A, B, C and D, and SCI was made by Allen's mode(10 g×25 mm) on spinal cord T9 extradually, 12 rats in each group. On the 1st d, 3rd d and 7th d after SCI, the recovery of motor function after spinal cord injury in rats was assessed with Basso-Beattie-Bresnahan(BBB)scale and slanting board test. Thiobarbituric acid was used to detect the concentration of malondialdehyde, and was observed the change of free radicals.ResultsAfter spinal cord injury in rats, BBB scores and slanting board test of groups A, B and C were better than group D. BBB scores and slanting board test of group C was better than groups A and B, which had significant difference on the 3rd d and 7th d after injury(P<0.05). After spinal cord injury in rats, concentration of malondialdehyde of groups A, B and C were lower than group D(P<0.05). Concentration of malondialdehyde of group C was lower than groups A and B, which had significant difference after injury(P<0.05).ConclusionMagnesium sulfate combined with GM1 can promote the recovery of motor function early after spinal cord injury in rats, and is superior to magnesium sulfate or GM1.
