Association of Intron rs12138592 A/G polymorphism of Ubiquitin Specific Proteases (USP24) Gene with Parkinson Disease
- VernacularTitle:泛素特异蛋白酶24基因内含子rs12138592 A/G位点多态性与帕金森病的关系
- Author:
Zhijun LIN
;
Yusen CHEN
;
Wenchuan XIAN
;
Jun CHEN
;
Wangtao ZHONG
;
Zhien XU
;
Yongqian XING
;
Bin ZHAO
- Publication Type:Journal Article
- Keywords:
ubiquitin specific proteases 24 gene, single-nucleotide polymorphism, Parkinson disease
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between Parkinson disease (PD) and intron rs12138592 A/G polymorphism of ubiquitin specific proteases (USP24) gene in Han population of the Western Guangdong province in China. Methods81 PD cases and 100 ethnically matched controls were investigated USP24 gene rs12138592 A/G polymorphism with polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). ResultsThe incidence of GG genotype was 77.8% in the cases and 62.0% in the controls (χ2=5.213,P=0.022), and the G allele was 88.3% in the cases, 79.5% in the controls (χ2=4.980，P=0.026). ConclusionThe G allele and GG genotype of USP24 gene rs12138592 A/G polymorphism can increase the risk of suffering from PD.
