Regulation of Diabetic Foot Ulcer-related Cytokines by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20230392
- VernacularTitle:中医药对糖尿病足溃疡相关细胞因子调控作用的研究进展
- Author:
Xiaqing GUO
1
;
Juanjiao DU
2
;
Shiqing YE
1
;
Xixi WANG
1
;
Yan CAO
1
;
Zhongjian CHEN
1
;
Dongmin XU
1
;
Ying YANG
1
Author Information
1. Guangxi University of Chinese Medicine， Nanning 530001， China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
diabetic foot ulcer;
cytokine;
inflammatory cytokine;
growth factor;
chemokine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):263-272
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic foot ulcer is a serious and destructive complication of diabetes， with the rates of disability and mortality increasing year by year， which poses a serious threat to human physical and mental health. In the treatment of diabetic foot ulcer with traditional Chinese medicine （TCM）， the combination of syndrome differentiation and overall concept can not only alleviate TCM syndrome but also accelerate wound healing， reduce wound recurrence， delay the further deterioration of diabetic foot ulcer， and decrease the rates of disability and mortality. Modern studies have demonstrated that the difficult healing of diabetic foot ulcer is closely associated with the abnormal distribution of cytokines such as inflammatory cytokines， growth factors， and chemokines. With the deepening of modern medical research on TCM， the treatment of diabetic foot ulcer via regulation of cytokines by Chinese medicinal monomers and prescriptions has become a research focus. This paper summarizes the current research status at home and abroad and draws the following conclusions. ① Sesamol， geniposide， Danggui Buxuetang， and Zizhu ointment can regulate tumor necrosis factor-α （TNF-α）， interleukin （IL）-1， IL-6， IL-10 and other inflammatory cytokines to inhibit wound inflammation. ② Angelicae Dahuricae Radix， salvianolic acid B， Sixiao powder， Badu Shengji ointment （Zhuang medicine）， etc.， regulate vascular endothelial growth factor （VEGF）， platelet-derived growth factor （PDGF）， transforming growth factor （TGF）， epidermal growth factor （EGF） and other growth factors to promote collagen deposition and angiogenesis on wound surface. ③ Paeoniflorin， cryptanshinone， bee venom， and Huiyang Shengji decoction regulate CXC chemokine ligand （CXCL） 1， CXCL2， C-C chemokine ligand （CCL） 2， CCL3， stromal cell-derived factor-1α （SDF-1α）， monocyte chemoattract protein-1 （MCP-1） and other chemokines to reduce inflammatory response and promote neovascularization and wound granulation tissue formation. ④ In the treatment of diabetic foot ulcer， Chinese medicinal monomers and prescriptions have different and complicated mechanisms. The multi-target treatment manner determines that Chinese medicines can act on a variety of cytokines to participate in various stages of wound healing and thus play a therapeutic role. The conclusion above aims to provide ideas for the experimental research and clinical treatment of diabetic foot ulcer with TCM in the future.
