Chinese Medicine Monomers in Treatment of Osteosarcoma by Regulating PI3K/Akt/mTOR Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20221527
- VernacularTitle:中药单体调控PI3K/Akt/mTOR信号通路治疗骨肉瘤的研究进展
- Author:
Haodong YANG
1
;
Ning LI
1
;
Xingwen XIE
2
;
Juxian DING
3
;
Bo LIU
3
;
Kai LIU
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730000， China
3. Second Provincial People's Hospital of Gansu， Affiliated Hospital of Northwest Minzu University， Lanzhou 730030， China
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin （PI3K/Akt/mTOR） signaling pathway;
Chinese medicine;
Chinese medicine monomer;
tumor cell
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):254-262
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma， a common primary bone malignancy， features high heterogeneity， poor prognosis， high propensity for local invasion and distant metastasis， and high mortality. At the moment， the major therapy is the combination of neoadjuvant chemotherapy and limb salvage surgery， which remarkably reduces the disability rate and fatality rate. However， long-term use of chemotherapeutic drugs leads to the acquisition of drug resistance by osteosarcoma cells and reduces the sensitivity of the tumor cells to the drugs. Thus， this therapy is not satisfactory. In recent years， amid the advancement in the treatment of tumor， Chinese medicine has attracted extensive attention for the obvious therapeutic effect and few adverse reactions. Phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） /mammalian target of rapamycin （mTOR） signaling pathway， as a classic cancer signaling pathway， is abnormally activated in osteosarcoma cells， which affects the proliferation， invasion， and metastasis of osteosarcoma cells by influencing the cycle of tumor cells， inhibiting apoptosis and autophagy of tumor cells， and promoting tumor angiogenesis. According to clinical research， Chinese medicine monomers influence proliferation， apoptosis， and autophagy of osteosarcoma cells and angiogenesis by regulating the activity of proteins in PI3K/Akt/mTOR signaling pathway， thereby suppressing osteosarcoma tissues and cells. Moreover， they can reverse the resistance of tumor cells to multiple anticancer drugs. Based on the knowledge and experience of Chinese medicine in the treatment of osteosarcoma， this paper reviews the role of PI3K/Akt/mTOR signaling pathway in the treatment of osteosarcoma by Chinese medicine monomers， which is expected to serve as a reference for the application of Chinese medicine in the treatment of osteosarcoma.
