Pathways Involved in Treatment of Endometriosis with Chinese Medicines： A Review
10.13422/j.cnki.syfjx.20222243
- VernacularTitle:中医药治疗子宫内膜异位症的相关通路研究进展
- Author:
Weisen FAN
1
;
Jiao LIU
2
;
Yingjie ZHANG
1
;
Dandan WANG
1
;
Yinghua QI
3
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM），Jinan 250014，China
2. Hebei University of Chinese Medicine，Shijiazhuang 050200，China
3. Affiliated Hospital of Shandong University of TCM，Jinan 250014，China
- Publication Type:Journal Article
- Keywords:
Chinese medicines;
endometriosis;
pathways;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):233-243
- CountryChina
- Language:Chinese
-
Abstract:
The in-depth study of the intervention of endometriosis （EMS） with Chinese medicines has revealed many pathways that can be regulated by Chinese medicines in the treatment of EMS. Chinese medicinal compound prescriptions， single Chinese herbal medicines， or their active ingredients treat EMS via the signaling pathways discussed in this paper. They can directly or indirectly regulate the expression of key molecules in the corresponding signaling pathways to inhibit the proliferation of endometriotic cells and the inflammatory changes of endometrial tissue， promote the apoptosis of endometriotic cells， change the pain threshold， and reduce endometriotic cell invasion， so as to achieve the therapeutic effects of inhibiting EMS progression， improving endometrial receptivity， and reducing ovarian injury. The following details are based on relevant studies conducted both at home and abroad. Curcumol can inhibit angiogenesis and promote cell apoptosis by blocking the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Icariin can reduce inflammation and promote cell apoptosis by blocking the nuclear factor-kappa B signaling pathway. Puerarin can suppress cell proliferation and promote cell apoptosis by inhibiting the mitogen-activated protein kinase （MAPK） signaling pathway and blocking the estrogen signaling pathway. Naringenin has the ability to activate the MAPK signaling pathway to promote cell apoptosis. Imperatorin can inhibit cell proliferation and promote cell apoptosis by inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway. Resveratrol can inhibit cell proliferation and alleviate fibrosis and adhesion by blocking the transforming growth factor-beta signaling pathway. Paeonol can inhibit angiogenesis by blocking the hypoxia-inducible factor 1 signaling pathway. The above summary can serve as a reference for the future clinical treatment or experimental research of EMS with Chinese medicines.
