Chinese Medicine Monomers in Treating Osteoporosis by Targeting Autophagy： A Review
10.13422/j.cnki.syfjx.20221630
- VernacularTitle:中药单体通过靶向自噬治疗骨质疏松症的研究进展
- Author:
Zhichao LI
1
;
Haipeng XUE
2
;
Hui SU
1
;
Zhanwang XU
2
;
Guoqing TAN
2
Author Information
1. Shandong University of Traditional Chinese Medicine （TCM）， Jinan 250014， China
2. Affiliated Hospital of Shandong University of TCM， Jinan 250014， China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
Chinese medicine monomers;
autophagy;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):194-202
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis， a common metabolic bone disease， is caused by the imbalance of bone homeostasis. Bone homeostasis depends on the dynamic balance between bone resorption by osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts and involves a series of complex and highly regulated steps. When bone resorption is faster than bone formation， bone homeostasis will be destroyed， which will lead to osteoporosis. Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis. The basal level of autophagy is present in all the three types of bone cells. Autophagy is a process whereby damaged organelles are recycled and bone remodeling continues， and thus it plays an important role in bone maintenance. Therefore， it is possible to regulate bone metabolism by targeting specific autophagy-related molecules. At the same time， as the research on the treatment of osteoporosis by Chinese medicine advances， it is found that the monomers isolated from traditional Chinese medicinals have the potential of regulating autophagy in the treatment of osteoporosis. Thus， this paper discusses the relationship between autophagy and osteoporosis and summarizes six different mechanisms of 22 Chinese medicine monomers in the treatment of osteoporosis through targeting autophagy： increasing osteogenic differentiation of mesenchymal stem cells， promoting osteoblast mineralization， inhibiting osteoclasts differentiation， reducing apoptosis of bone cells， antagonizing oxidative stress injury， and coordinating inflammation and autophagy levels. The review is expected to provide a reference and ideas for future research on the treatment of osteoporosis by Chinese medicine monomers.
