Relationship Between NLRP3 Inflammasome and Depression and Intervention Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20230391
- VernacularTitle:NLRP3炎症小体与抑郁症的关系及中医药的干预作用
- Author:
Nan ZHANG
1
;
Erping XU
1
;
Yulong CHEN
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Review
- Keywords:
NOD-like receptor family， pyrin domain-containing 3 （NLRP3） inflammasome;
depression;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):186-193
- CountryChina
- Language:Chinese
-
Abstract:
Depression， a mental disorder with high incidence， threatens people's health and causes heavy economic burden. In recent years， the research on the pathogenesis of depression is no longer limited to neurotransmitters， hypothalamic-pituitary-adrenal axis， and oxidative stress， and neuroinflammation draws increasing attention. Studies have demonstrated that the NOD-like receptor family， pyrin domain-containing 3 （NLRP3） inflammasome as a bridge connecting psychological stress and depression can initiate inflammatory cascade to induce depression. This article expounds the relationship between NLRP3 inflammasome and depression and introduces the mechanisms and targets of NLRP3 inflammasome in regulating depression. Further， we summarize the research progress in the treatment of depression with traditional Chinese medicine， which regulates NLRP3 inflammasomes to reduce the release of inflammatory cytokines. This review is expected to provide new ideas for the prevention and treatment of depression.
