Autophagy of Vascular Endothelial Cells Influences Diabetic Macroangiopathy： Based on Theory of Qi Deficiency and Stagnation
10.13422/j.cnki.syfjx.2022002021
- VernacularTitle:基于“虚气留滞”理论探讨血管内皮细胞自噬对糖尿病大血管病变的影响
- Author:
Qingzhi LIANG
1
;
Zhengtao CHEN
1
;
Yulin LENG
1
;
Zehua ZHANG
1
;
Qiyue YANG
1
;
Hong GAO
1
;
Chunguang XIE
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610075，China
- Publication Type:Journal Article
- Keywords:
Qi deficiency and stagnation;
autophagy;
diabetic macroangiopathy;
vascular endothelial cells;
atherosclerosis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):178-185
- CountryChina
- Language:Chinese
-
Abstract:
The basic pathological change of diabetic macroangiopathy is atherosclerosis （AS）， which is mainly associated with vascular endothelial cells （VECs） injury， oxidative stress， glucose and lipid metabolism disorders， hemorheological abnormalities， and endoplasmic reticulum stress. The injury and dysfunction of VECs are the initiating factors of diabetic macroangiopathy. Autophagy is a subcellular self-protection mechanism that regulates basic intracellular metabolism through lysosome-mediated degradation of proteins and damaged organelles to maintain homeostasis. Insufficient autophagy of VECs leads to enhanced inflammation， apoptosis， and oxidative stress of VECs， which promotes AS. According to the theory of traditional Chinese medicine （TCM）， diabetic macroangiopathy corresponds to the syndrome of internal deficiency and pathogen invasion， with Qi deficiency and stagnation as the key pathogenesis. Qi deficiency is the root cause， and Qi stagnation is the manifestation. The disease occurs with the initial cause of nutrient-defense disharmony and instability of vessels， the main cause of the deficiency of kidney Qi and the lack of source for generation and transformation， the internal cause of Qi and blood loss in the viscera and the stagnation of Qi， blood， and fluid， and the superficial cause of the stagnation of pathological products and the damage of vessels. Autophagy is a microscopic manifestation of Qi， which has the function of dispelling pathogens and maintaining homeostasis. Insufficient autophagy of VECs leads to Qi deficiency and stagnation， and the gradual deficiency and heavy stagnation of Qi lead to insufficient autophagy， which form a vicious cycle. Modern research has demonstrated that regulating the autophagy of VECs is the main way to prevent and treat AS， and TCM can exert the therapeutic effect in a multi-target and multi-pathway manner. Therefore， based on the theory of Qi deficiency and stagnation， the method of tonifying deficiency of and removing stagnation can be adopted to select prescriptions for regulating the autophagy of VECs and treating AS， which can slow down the procession of diabetic macroangiopathy.
