Discussion on Microdysbiosis in COPD Based on ''Lung-Spleen-Intestine'' Mode of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20221821
- VernacularTitle:“肺-脾-肠”的中医模式探讨COPD微生态失调
- Author:
Xiaohong ZHANG
1
;
Peiyi WANG
1
;
Shixiao ZHANG
1
;
Wang TAO
1
;
Jie SUN
2
Author Information
1. Guangzhou University of Chinese Medicine，Guangzhou 510000，China
2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510000，China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease（COPD）;
intestinal flora;
microecology;
lung-spleen-intestine;
lung-gut axis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):170-177
- CountryChina
- Language:Chinese
-
Abstract:
Owing to the advancement of high-throughput microbial 16S ribosomal RNA （16S rRNA） gene sequencing， respiratory and intestinal flora has become a research hotspot in China and abroad in recent years. At the moment， it has been verified that intestinal flora is closely related to various respiratory diseases such as cystic fibrosis， chronic obstructive pulmonary disease （COPD）， asthma， and lung infection. The causal relationship between COPD and intestinal flora is still unclear. In clinical settings， COPD is characterized by gastrointestinal disorders such as anorexia， abdominal distension， and constipation， and malnutrition， which are closely related to the imbalance of intestinal flora. According to modern medicine， intestinal microbiota participates in the metabolism of energy and nutrients and immune defense in the host through the common mucosal immune system， thereby involving the progression of diseases. In addition， metabolites of intestinal flora mediate lung immune dysfunction through the immunoregulation of remote organs， causing pulmonary and intestinal microdysbiosis and affecting the occurrence and development of COPD. COPD belongs to the category of "lung distension" in traditional Chinese medicine （TCM）. The pathogenesis of microdysbiosis in COPD is closely related to the lung， spleen， and intestine. Particularly the transportation and transformation of water and grains and the defense against external pathogens in TCM are consistent with the mechanisms of intestinal flora disturbance in COPD in modern medicine. The interior-exterior relationship between lung and large intestine， linkage between spleen and small intestine， and lung and spleen in the meridian of taiyin in TCM can well explain the microdysbiosis in COPD. Based on available research outcomes in modern medicine， this paper discusses the relationship between the flora in lung and intestine and microdysbiosis in COPD in TCM. The author believes that the "lung-spleen-intestine" mode in TCM is a new perspective for the research on microdysbiosis in COPD， which is conducive to the prevention and treatment of COPD.
