Effect of Wuwei Fuzheng Yijing Decoction on Sperm DNA Integrity in Male Infertility Patients
10.13422/j.cnki.syfjx.20230397
- VernacularTitle:五味扶正益精汤对男性不育患者精子DNA完整性的影响
- Author:
Panpan ZHAO
1
;
Zulong WANG
2
;
Rubing CHEN
2
Author Information
1. Chinese Medicine Hospital of Puyang，Puyang 457000，China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
sperm DNA integrity;
sperm DNA fragmentation index （DFI）;
male infertility;
Wuwei Fuzheng Yijing decoction;
vital Qi deficiency leading to easy invasion of pathogenic Qi;
Wuzi Yanzongwan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(3):127-132
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of Wuwei Fuzheng Yijing decoction on sperm DNA integrity in male infertility patients. MethodOne hundred male infertility patients with sperm DNA damage （spleen and kidney Qi deficiency and blood stasis） that met the inclusion criteria were randomly divided into an observation group （Wuwei Fuzheng Yijing decoction） and a control group （L-carnitine oral solution）， with 50 cases in each group. After 12 weeks of treatment， the DNA fragmentation index （DFI） and traditional Chinese medicine （TCM） syndrome score， progressive sperm motility （PR）， sperm survival rate， and sperm concentration of the two groups before and after treatment were observed and compared. ResultThe total effective rate of the observation group was 89.80% （44/49） higher than 62.50% （30/48） of the control group （P<0.05）. Compared with the conditions before treatment， the DFI and TCM syndrome score of the two groups were reduced after treatment， while the PR， sperm survival rate， and sperm concentration were increased （P<0.05）， and the observation group was superior to the control group in terms of the above indexes （P<0.05）. ConclusionWuwei Fuzheng Yijing decoction obviously repairs sperm DNA of male infertility patients and improves sperm quality， with high safety.
