Research progress of transient potential receptor vanilloid 4 in ophthalmic diseases
10.3980/j.issn.1672-5123.2023.1.09
- VernacularTitle:TRPV4在眼科疾病中的研究进展
- Author:
Feng WANG
1
;
Jiang-Feng LAI
1
;
Ling-Ying CAO
1
;
Yi SHAO
1
Author Information
1. Department of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
transient potential receptor vanilloid 4(TRPV4);
corneal epithelial injury;
glaucoma;
age-related cataract;
retina
- From:
International Eye Science
2023;23(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Transient potential receptor vanilloid 4(TRPV4)is a cluster of non-selective cation channels presented on cell membranes. They are important mediators of sensory signals that regulate cell function and signaling pathways. TRPV4 is widely expressed in various ocular tissues and can participate in a variety of physiological functions, including osmotic pressure regulation, Ca2+ homeostasis, apoptosis and autophagy. It plays an important role in normal physiological functions and different pathology. Recent studies have revealed that TRPV4 is closely correlated to corneal epithelial injury, glaucoma, age-related cataract, diabetic retinopathy, retinopathy of prematurity, retinal detachment and other diseases. Besides, studies also showed that TRPV4 regulates the occurrence and development of its related ophthalmic diseases. This paper briefly reviewed the research progress on TRPV4 pathway in ophthalmic diseases, so as to provide ideas for the clinical treatment of ophthalmopathy.
