Correlation between Complete Blood Count， Glycosylated Hemoglobin and Thyroid Function in Late Pregnancy on Tibetan Plateau
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0618
- VernacularTitle:藏族高海拔地区妊娠晚期全血细胞计数、糖化血红蛋白及甲状腺功能的相关性研究
- Author:
Jin-hui CUI
1
;
Ping LI
1
;
Xiao-yu CHEN
2
;
Qiang LIU
2
;
Ya-ting LIANG
2
;
Zhuoga DAWA
2
;
Ma NI
2
;
Jian-hui FAN
1
Author Information
1. Department of Obstetrics， The Third Affiliated Hospital， Sun Yat-sen University， Guangzhou 510630， China
2. Department of Obstetrics and Gynecology， Chaya People's Hospital， Changdu City， Tibet Autonomous Region， Changdu 854300， China
- Publication Type:Journal Article
- Keywords:
Tibetan;
Plateau;
late pregnancy;
complete blood count;
glycosylated hemoglobin;
thyroid function
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(6):1020-1027
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the correlation between complete blood count （CBC）， glycosylated hemoglobin（GHbA1c）and thyroid function in late pregnancy on Tibetan Plateau. MethodsA retrospective analysis was performed on 374 patients of single pregnancies who had delivered in the department of Obstetrics and Gynecology， Chaya People's Hospital， Changdu City， Tibet Autonomous Region， between January 1， 2021 and December 31， 2021. All subjects completed CBC， GHbA1c and total triiodothyronine（TT3）， total thyroxine（TT4）， thyroid stimulating hormone（TSH）before delivery. According to the altitude of long-term residence， they were divided into three groups： the altitude of group A is <3500 m； the altitude of group B is 3 500~4 000 m； and the altitude of group C is ＞4 000 m. The anemia of Tibetan pregnant women in late pregnancy before and after adjustment， the levels of CBC， GHbA1c and thyroid function in different altitudes， and their correlations were analyzed. Results① The mean actual hemoglobin（HB）was 120.0（108.0~130.0）g/L， and the prevalence of anemia was 27.8%（104/374）. After adjustment， the mean HB was 93.0（80.0~104.0）g/L， and the prevalence of anemia was 84.3 %（315/374）； ② Actual HB levels increased with the rise of altitude， but the difference was not statistically significant（P>0.05）， and there was no difference among the three groups in the prevalence of anemia. After adjustment， HB levels showed a downward trends， while the prevalence of anemia increased with the rise altitude， and the difference was statistically significant（P＜0.001）. ③ Red blood cell count（RBC）and mean erythrocyte hemoglobin concentration（MCHC）increased， while TSH decreased with the rise of altitude， and the difference was statistically significant（P＜0.05）. ④ The actual HB and MCHC were positively correlated with TT4， GHbA1c was negatively correlated with TT4， and positively correlated with Platelet count （PLT）； spearman correlation analysis showed statistical significance（P＜0.05）. ConclusionsThe actual HB of Tibetan Plateau pregnant women in late pregnancy does not increase significantly with the rise of altitude. The prevalence of anemia increases significantly after adjustment according to the altitude. TSH decreases with the rise of altitude， and the altitude may have an effect on thyroid function in late pregnancy. Actual anemia in late pregnancy is associated with low T4， and low T4 and high PLT might be associated with increased GHbA1c. Actual HB， PLT and T4 in late pregnancy are expected to be predictors of thyroid disease and GDM.
