Visualized Precise Electro- physiological Diagnosis and Treatment of Peyronie's Disease in Plateau Areas
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0603
- VernacularTitle:高原地区应用可视化精准电生理诊断与治疗佩罗尼氏病
- Author:
Wei GUO
1
;
Ji-xiong YAN
1
;
Qiang ZHANG
1
;
Qi-wei CHEN
1
;
Rong-rong YANG
1
Author Information
1. Andrology department， The first people's Hospital of Xining， Xining 810000， China
- Publication Type:Journal Article
- Keywords:
Peyronie’s disease;
TMT image;
electrophysiological diagnosis;
percutaneous low frequency electrical stimulation
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(6):884-891
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the efficacy and treatment options of precise electrophysiological diagnosis combined with percutaneous low-frequency electrical stimulation for penile scleroderma in high-altitude hypoxic areas. MethodsA total of 54 patients with electrophysiological diagnosis and treatment of corpora cavernosa were included in the retrospective analysis. Their age ranged from 20 to 70 years with a mean of 45.5±11.6 years and disease duration from 2 to 16 months. PDE5i， levocarnitine oral solution， and traditional Chinese medicine for invigorating blood circulation and eliminating stasis were administered orally before treatment. The visual precision electrophysiological diagnosis was performed after discontinuation of all oral drugs for 1 week before treatment. The electrophysiological diagnostic parameters were recorded and contrasted before and after the set-up treatment， and the corresponding parameters for precision electrophysiology were adjusted for percutaneous low-frequency electrical stimulation treatment， 2-3 hours each time， once daily， and 10 times per course. At the same time was administered assisted nasal cannula oxygen inhalation for 2 to 3 hours （4L/min）. Before and after electrophysiological diagnosis and treatment were evaluated by using the numeric assessment scale of pain extent， the international index of erectile function score （IIEF-5）， penile curvature measurement， color Doppler measurement of plaque areas and comparison of whole body and disease local infrared thermogram temperature changes. ResultsAll patients successfully completed 2-4 sessions of percutaneous low-frequency electrical stimulation （20 sessions to 40 sessions）. There was a significant statistical difference （P < 0.01） between the mean values before and after treatment for the degree of weakness / erection pain （7.1±1.6 vs 2.0±1.0）；（8.2±3.2 vs 16.0±5.1） before and after IIEF-5 treatment， respectively （P < 0.01），Pre- and post-treatment of PCDDU measured mean plaque size was 0.23（0.09~0.54）cm2 vs 0.23（0.09~0.54）cm2，with no statistically different change in improvement value （P = 0.189）. Four cases had no penile camptodactyly， Before electrical stimulation， 50 （92.6%） patients had different degrees of penile curvature deformity， and there was no change in the improvement of the contrast bending angle before and after treatment （P >0.05）. The comparison of TMT images before and after treatment with visual precision electrophysiology diagnosis suggested that temperature change >1.5℃ in the whole body and penile and bilateral inguinal regions， etc. could be considered effective electrical stimulation treatment. There were no recurrences of induration， increased pain and penile curvature at 3~10 months follow-up， and no patient required subsequent surgery. ConclusionThe results of this study show that visualizing the electrophysiological diagnosis situation to set local and holistic combined treatment parameters， and treating PD by means of percutaneous low-frequency electrical stimulation at meridian and neuromuscular acupoints of traditional Chinese medicine could achieve good safety and efficacy， especially in the early stage，which has a clear effect on pain treatment， thus opening new avenues for PD treatment.
