An Autopsy Case of Multiple System Atrophy.
- Author:
Jung Hwan LEE
1
;
Sook Keun SONG
;
Sang Kyum KIM
;
Tai Seung KIM
;
Phil Hyu LEE
Author Information
1. Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.
- Publication Type:Case Report
- Keywords:
Multiple-system atrophy;
Autopsy;
Glial cytoplasmic inclusion
- MeSH:
Atrophy;
Autopsy;
Basal Ganglia;
Brain Stem;
Cerebellar Ataxia;
Cerebellum;
Inclusion Bodies;
Korea;
Multiple System Atrophy;
Neurodegenerative Diseases;
Neurons;
Parkinsonian Disorders;
Spinal Cord
- From:Journal of the Korean Neurological Association
2010;28(1):56-58
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple-system atrophy (MSA) is an adult-onset, sporadic, progressive neurodegenerative disease. Clinically, the cardinal features include autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs in any combination, of which autonomic failure is an integral component in the diagnosis. Pathologically, MSA is characterized by alpha-synuclein-positive glial cytoplasmic inclusions and neuronal loss, predominantly in the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord. We report the first case of MSA confirmed by autopsy in Korea.
