Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation
- VernacularTitle:基于免疫调节探讨茶多酚及表没食子儿茶素没食子酸酯的抗肿瘤机制
- Author:
Guangda LI
1
;
Jing WANG
1
;
Jing XU
1
;
Meiwen XIE
1
;
Yibin ZHOU
1
;
Li HOU
1
Author Information
1. Dept. of Oncology and Hematology，Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
tea polyphenols;
epigallocatechin gallate;
immunoregulation;
immune effect;
immune escape;
antitumor
- From:
China Pharmacy
2022;33(24):3067-3072
- CountryChina
- Language:Chinese
-
Abstract:
Tea polyphenol （TP） is the main active constituent in tea， and epigallocatechin gallate （EGCG） is the main active constituent of TP that plays a biological role. Both of them can be used as immunomodulators in the treatment of tumor. In this paper， the anti-tumor mechanism of TP and EGCG was summarized from two aspects： enhancing immune effect and improving immune escape. The results showed that TP and EGCG could not only enhance the anti-tumor immune effect by promoting the activity of immune cells and the secretion of cytokines， but also improve tumor immune escape by regulating immunosuppressive cells， immune checkpoints， cytokines， immunomodulatory enzymes and JAK/STAT pathway， which has great potential in tumor immunotherapy.
