FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus

Author: Yang NI ¹ ; Bin LIU ¹ ; Xiaojing WU ¹ ; Junhua LIU ¹ ; Ru BA ¹ ; Chunjie ZHAO ¹
Author Information

1. Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, School of Medicine, Southeast University
Publication Type:Journal Article
Keywords: dendritic arborization; Foxg1; granule cell; hippocampus; mossy fiber; pyramidal neuron; Wnt; Wnt5a
From: Neuroscience Bulletin 2021;37(3):298-310
CountryChina
Language:Chinese
Abstract: The Wnt signaling pathway plays key roles in various developmental processes. Wnt5a, which activates the non-canonical pathway, has been shown to be particularly important for axon guidance and outgrowth as well as dendrite morphogenesis. However, the mechanism underlying the regulation of Wnt5a remains unclear. Here, through conditional disruption of Foxg1 in hippocampal progenitors and postmitotic neurons achieved by crossing Foxg1