Decoding Cortical Glial Cell Development

Author: Xiaosu LI ¹ ; Guoping LIU ¹ ; Lin YANG ¹ ; Zhenmeiyu LI ¹ ; Zhuangzhi ZHANG ¹ ; Zhejun XU ¹ ; Yuqun CAI ¹ ; Heng DU ¹ ; Zihao SU ¹ ; Ziwu WANG ¹ ; Yangyang DUAN ¹ ; Haotian CHEN ¹ ; Zicong SHANG ¹ ; Yan YOU ¹ ; Qi ZHANG ¹ ; Miao HE ¹ ; Zhengang YANG ¹ ; Bin CHEN ²
Author Information

1. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontiers Center for Brain Science, Department of Neurology, Institute for Translational Brain Research, Zhongshan Hospital, Fudan University
2. Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz
Publication Type:Journal Article
Keywords: ASCL1; Astrocyte; Cerebral cortex; EGFR; Intermediate progenitor cell; Olfactory bulb interneuron; OLIG2; Oligodendrocyte; Radial glial cell
From: Neuroscience Bulletin 2021;37(4):440-460
CountryChina
Language:Chinese
Abstract: Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1