Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

Ti-fei Yuan; Ti-fei Yuan; Kwok-fai SO; Ti-fei Yuan; Chun Yao; Yongjun Wang; Renjie Chai; Yan Liu; Yi Dong; Li Zhang; Kwok-fai SO; Li Zhang; Kwok-fai SO; Jieyu QI; Renjie Chai; Chun Yao; Yongjun Wang; Yan Liu

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Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives

Author: Ti-Fei YUAN ¹ ; Ti-Fei YUAN ² ; Kwok-Fai SO ² ; Ti-Fei YUAN ³ ; Chun YAO ³ ; Yongjun WANG ³ ; Renjie CHAI ³ ; Yan LIU ³ ; Yi DONG ⁴ ; Li ZHANG ⁵ ; Kwok-Fai SO ⁵ ; Li ZHANG ⁶ ; Kwok-Fai SO ⁶ ; Jieyu QI ⁷ ; Renjie CHAI ⁷ ; Chun YAO ⁸ ; Yongjun WANG ⁸ ; Yan LIU ⁹
Author Information

1. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
2. State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong
3. Co-innovation Center of Neuroregeneration, Nantong University
4. Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University
5. Joint International Research Laboratory of CNS Regeneration, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University
6. Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area
7. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University
8. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University
9. Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University
Publication Type:Journal Article
Keywords: Deep brain stimulation; Neuromodulation; Rehabilitation; Stem cell; Transcranial direct current stimulation; Transcranial magnetic stimulation
From: Neuroscience Bulletin 2021;37(5):735-745
CountryChina
Language:Chinese
Abstract: Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site, orchestrate the differentiation process, and promote the integration of neural circuitry for functional rehabilitation. All these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation.