Polymodal Functionality of C. elegans OLL Neurons in Mechanosensation and Thermosensation

Author: Yuedan FAN ¹ ; Wenjuan ZOU ¹ ; Jia LIU ¹ ; Umar AL-SHEIKH ¹ ; Hankui CHENG ¹ ; Duo DUAN ¹ ; Duo DU CHEN ¹ ; Siyan LIU ¹ ; Lijun KANG ¹ ; Yuedan FAN ² ; Wenjuan ZOU ² ; Jia LIU ² ; Umar AL-SHEIKH ² ; Hankui CHENG ² ; Duo DUAN ² ; Duo DU CHEN ² ; Siyan LIU ² ; Lijun KANG ² ; Luyi CHEN ³ ; Jilei XU ³ ; Firdosh RUHOMUTALLY ⁴
Author Information

1. Department of Neurobiology and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine
2. NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University
3. Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
4. Department of Human Sciences and Psychology, University of South Africa (UNISA)
Publication Type:Journal Article
Keywords: Cold receptor; Mechanosensation; OLL neurons; Polymodal sensory neuron; Sodium channel; Thermosensation
From: Neuroscience Bulletin 2021;37(5):611-622
CountryChina
Language:Chinese
Abstract: Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral (OLL) sensilla sensory neurons respond to touch and cold. Mechanosensation of OLL neurons resulted in cell-autonomous mechanically-evoked Ca