Glucose Protects Cochlear Hair Cells Against Oxidative Stress and Attenuates Noise-Induced Hearing Loss in Mice

Author: Hao XIONG ¹ ; Lan LAI ¹ ; Yongyi YE ¹ ; Yiqing ZHENG ¹ ; Hao XIONG ² ; Lan LAI ² ; Yongyi YE ² ; Yiqing ZHENG ²
Author Information

1. Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
2. Institute of Hearing and Speech-Language Science, Sun Yat-sen University
Publication Type:Journal Article
Keywords: Cochlea; Glucose; Hair cell; Hearing loss; Oxidative stress
From: Neuroscience Bulletin 2021;37(5):657-668
CountryChina
Language:Chinese
Abstract: Oxidative stress is the key determinant in the pathogenesis of noise-induced hearing loss (NIHL). Given that cellular defense against oxidative stress is an energy-consuming process, the aim of the present study was to investigate whether increasing energy availability by glucose supplementation protects cochlear hair cells against oxidative stress and attenuates NIHL. Our results revealed that glucose supplementation reduced the noise-induced formation of reactive oxygen species (ROS) and consequently attenuated noise-induced loss of outer hair cells, inner hair cell synaptic ribbons, and NIHL in CBA/J mice. In cochlear explants, glucose supplementation increased the levels of ATP and NADPH, as well as attenuating H