Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment
10.1007/s12264-021-00657-0
- Author:
Wenhao ZHU
1
;
Hao HUANG
1
;
Xiang LUO
1
;
Shabei XU
1
;
Qi MENG
1
;
Chengchao ZUO
1
;
Wei WANG
1
;
Shiqi YANG
2
;
Wenzhen ZHU
2
;
Yong LIU
3
;
Yong LIU
4
;
Yong LIU
5
Author Information
1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
2. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
3. Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences
4. School of Artificial Intelligence, Beijing University of Posts and Telecommunications
5. University of the Chinese Academy of Sciences
- Publication Type:Journal Article
- Keywords:
Cognitive impairment;
Cortical thickness;
Grey matter volume;
Replication;
White matter hyperintensities
- From:
Neuroscience Bulletin
2021;37(6):789-803
- CountryChina
- Language:Chinese
-
Abstract:
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment (WMH-MCI), 43 WMH patients without cognitive impairment, and 55 healthy controls. Both WMH groups showed GM atrophy in the bilateral thalamus, fronto-insular cortices, and several parietal-temporal regions, and the WMH-MCI group showed more extensive and severe GM atrophy. The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients. Furthermore, the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses. These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.
