Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications
10.1007/s12264-021-00638-3
- Author:
Zezhi LI
1
;
Jun CHEN
1
;
Yiru FANG
1
;
Zezhi LI
2
;
Meihua RUAN
3
;
Yiru FANG
4
;
Jun CHEN
5
;
Yiru FANG
5
Author Information
1. Clinical Research Center and Division of Mood Disorders of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
2. Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
3. Shanghai Institute of Nutrition and Health, Shanghai Information Center for Life Sciences, Chinese Academy of Science
4. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science
5. Shanghai Key Laboratory of Psychotic Disorders
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Pathogenesis;
Progress;
Treatment
- From:
Neuroscience Bulletin
2021;37(6):863-880
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease caused by the interaction of social, psychological, and biological aspects. Therefore, there is no exact pathological theory that can independently explain its pathogenesis, involving genetics, neurobiology, and neuroimaging. At present, there are many treatment measures for patients with depression, including drug therapy, psychotherapy, and neuromodulation technology. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in the clinic. This article mainly reviews the research progress, pathogenesis, and treatment of MDD.
