Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice

Xinyi Zhou; Wenhao Liu; Qian Xiao; Pengfei Wei; Zhigang Zhang; Liping Wang; Jie TU; Xinyi Zhou; Pengfei Wei; Yue Liu; Jie Wang; Liping Wang; Jie TU; Bifeng WU; Wenhao Liu; Wei HE; Ying Zhou; Xu Zhang; Weidong LI; Yue Liu; Jie Wang; Jufang HE; Jufang HE

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Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice

Author: Xinyi ZHOU ¹ ; Wenhao LIU ¹ ; Qian XIAO ¹ ; Pengfei WEI ¹ ; Zhigang ZHANG ¹ ; Liping WANG ¹ ; Jie TU ¹ ; Xinyi ZHOU ² ; Pengfei WEI ² ; Yue LIU ² ; Jie WANG ² ; Liping WANG ² ; Jie TU ² ; Bifeng WU ³ ; Wenhao LIU ⁴ ; Wei HE ⁵ ; Ying ZHOU ⁶ ; Xu ZHANG ⁷ ; Weidong LI ⁷ ; Yue LIU ⁸ ; Jie WANG ⁸ ; Jufang HE ⁹ ; Jufang HE ¹⁰
Author Information

1. Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
2. University of Chinese of Academy of Sciences
3. Department of Information Technology and Electrical Engineering, Zurich Swiss Federal Institute of Technology Zurich
4. Department of Biomedical Sciences, City University of Hong Kong
5. Virginia Polytechnic Institute and State University
6. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine
7. Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University
8. Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences
9. Department of Neuroscience, City University of Hong Kong
10. City University of Hong Kong Shenzhen Research Institute
Publication Type:Journal Article
Keywords: DISC1; Nucleus accumbens; Parvalbumin; Risk avoidance
From: Neuroscience Bulletin 2021;37(9):1325-1338
CountryChina
Language:Chinese
Abstract: A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N