The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction

Author: Qian WANG ¹ ; Ying KONG ¹ ; Song LIN ¹ ; Ding-Yu WU ¹ ; Jian HU ¹ ; Lang HUANG ¹ ; Wen-Si ZANG ¹ ; Xiao-Wen LI ¹ ; Jian-Ming YANG ¹ ; Tian-Ming GAO ¹
Author Information

1. State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brian Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University
Publication Type:Journal Article
Keywords: Astrocyte; ATP; Calorie restriction; Depression; IP3R2
From: Neuroscience Bulletin 2021;37(9):1303-1313
CountryChina
Language:Chinese
Abstract: Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced mood modification. Previous studies have found that astrocytes modulate depressive-like behaviors. Inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is the predominant isoform in mediating astrocyte Ca