Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Author: Zhixin PENG ¹ ; Zengqiang YUAN ¹ ; Zhixin PENG ² ; Xiaoheng LI ² ; Yuhao GAO ² ; Zengqiang YUAN ² ; Jun LI ³ ; Yuan DONG ⁴ ; Yajin LIAO ⁵ ; Meichen YAN ⁵ ; Zengqiang YUAN ⁵ ; Jinbo CHENG ⁵
Author Information

1. Institute of Neuroscience, Hengyang Medical College, University of South China
2. The Brain Science Center, Beijing Institute of Basic Medical Sciences
3. Beijing Institute for Brain Disorders, Capital Medical University
4. Institutes of Brain Sciences and Disease, Medical College, Qingdao University
5. Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China
Publication Type:Journal Article
Keywords: Depression; Dlg1; Microglia; Neuroinflammation
From: Neuroscience Bulletin 2021;37(12):1671-1682
CountryChina
Language:Chinese
Abstract: Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K