In vitro α-amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus macroptera Montr. fruit
- Author:
Nizam UDDIN
1
;
Md. Rakib HASAN
1
;
Md. Monir HOSSAIN
1
;
Arjyabrata SARKER
1
;
Arjyabrata NAZMUL HASAN
1
;
Arjyabrata MAHMUDUL ISLAM
1
;
Mohd. Motaher H. CHOWDHURY
1
;
Md. Sohel RANA
1
Author Information
- Publication Type:Journal Article
- Keywords: Citrus macroptera; Diabetes mellitus; Glibenclamide; Hypoglycemic; OGTT; α-Amylase
- From:Asian Pacific Journal of Tropical Biomedicine 2014;4(6):473-479
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the therapeutic effects of methanol extract of Citrus macroptera Montr. fruit in α-amylase inhibitory activity (in vitro) and hypoglycemic activity in normal and glucose induced hyperglycemic rats (in vivo). Methods: Fruits of Citrus macroptera without rind was extracted with pure methanol following cold extraction and tested for presence of phytochemical constituents, α-amylase inhibitory activity, and hypoglycemic effect in normal rats and glucose induced hyperglycemic rats. Results: Presence of saponin, steroid and terpenoid were identified in the extract. The results showed that fruit extract had moderate α-amylase inhibitory activity [IC
