Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Abiodun Falodun; Vincent Imieje; Osayewenre Erharuyi; Ahomafor Joy; Abiodun Falodun; Mohammed Abaldry; Mark Hamann; Vincent Imieje; Osayewenre Erharuyi; Peter Langer; Melissa Jacob; Shabanna Khan

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Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Author: Abiodun FALODUN ¹ ; Vincent IMIEJE ¹ ; Osayewenre ERHARUYI ¹ ; Ahomafor JOY ¹ ; Abiodun FALODUN ² ; Mohammed ABALDRY ² ; Mark HAMANN ² ; Vincent IMIEJE ³ ; Osayewenre ERHARUYI ³ ; Peter LANGER ³ ; Melissa JACOB ⁴ ; Shabanna KHAN ⁴
Author Information

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin
2. Department of Pharmacognosy, School of Pharmacy, University of Mississippi
3. Institute of Organic Chemistry, University of Rostock
4. National Center for Natural Products Research, Institute of Pharmaceutical Sciences, University of Mississippi
Publication Type:Journal Article
Keywords: Antimalarial; Antimicrobial; Jatropha multifida; Leishmaniasis; Stem bark
From:Asian Pacific Journal of Tropical Biomedicine 2014;4(5):374-378
CountryChina
Language:Chinese
Abstract: Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods: The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC