In vitro and in vivo trypanocidal action of aescin and aescin liposomes against Trypanosoma evansi in experimental mice
- Author:
Matheus Dellaméa BALDISSERA
1
;
Thirssa Helena GRANDO
1
;
Carine Eloise PRESTES ZIMMERMAN
1
;
Janio Morais SANTURIO
1
;
Silvia Gonzalez MONTEIRO
1
;
Matheus Dellaméa BALDISSERA
2
;
Nathieli Bianchin BOTTARI
2
;
Roberto Christ VIANNA SANTOS
2
;
Roberto Christ VIANNA SANTOS
3
;
Ana Júlia FIGUEIRÓ DALCIN
3
;
Patrícia GOMES
3
;
Renata Platcheck RAFFIN
3
;
Aleksandro Schafer DA SILVA
4
Author Information
- Publication Type:Journal Article
- Keywords: Aesculus hippocastanum; Nanotechnology; Surra; Trypanosome
- From:Asian Pacific Journal of Tropical Biomedicine 2014;4(12):947-951
- CountryChina
- Language:Chinese
- Abstract: Objective: To verify the trypanocidal effectiveness of aescin and aescin liposomes against Trypanosoma evansi in vitro and in vivo. Methods: Aescin and aescin liposomes were used in vitro on trypomastigotes at different concentrations (0.5%, 1.0% and 2.0%) and exposure times (0, 1, 3, 6 and 9 h). In vivo tests were performed using mice as the experimental model. Trypanosome evansi infected mice were treated with aescin and aescin liposomes with doses of 60 and 100 mg/kg during 4 d. Results: The three concentrations tested in free form and nanoencapsulated showed trypanocidal activity in vitro, completely eliminating the parasites in small concentration after 6 h of assay. Animals treated with aescin (100 mg/kg) and aescin liposomes (100 mg/kg) showed increase in longevity, however without curative effect. Conclusions: Active compounds present in natural products, such as aescin, may potentiate the treatment of trypanosomosis when used in association with other trypanocidal drugs.
