High dose exposures of vinyl acetate induce neoplastic transformation of human epithelial cells in culture.
- Author:
Jun Hyun CHO
1
;
Chin Soo KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyungpook National University, Korea.
- Publication Type:Original Article
- Keywords:
Vinyl acetate;
Neoplastic transformation;
Human epithelial cell
- MeSH:
Adhesives;
Epithelial Cells*;
Humans*;
International Agencies;
Mouth;
Mouth Neoplasms;
Paint;
Polyvinyl Alcohol;
Textiles
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2007;33(5):437-444
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vinyl acetate has been widely used for the manufacture of polyvinyl alcohol emulsion, which is primary ingredient of adhesive, paints, textile, paperboard coatings, etc. Since these products are plentiful and frequently used around us, workers and consumers are at health risk. International Agency for Research on Cancer (IARC) classified vinyl acetate as group 2B (possibly carcinogenic to humans). Among the organs targeted, the oral cavity is the most vulnerable organ affected by the carcinogenic effects of vinyl acetate. Since the origin of most of oral cancer is derived from the epithelial cells, it is important to understand the carcinogenic potential of vinyl acetate in human epithelial cells. Thus, the present study has attempted to utilize the immortalized human epithelial cell model to assess the carcinogenic potency of this chemical and to understand the underlying mechanisms.
