Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties
10.12980/APJTB.4.2014APJTB-2013-0025
- Author:
Ezenyi Ifeoma CHINWUDE
1
;
Salawu Oluwakanyinsola ADEOLA
1
;
Ezenyi Ifeoma CHINWUDE
2
;
Kulkarni ROSHAN
2
;
Joshi SWATI
2
;
Emeje MARTINS
3
Author Information
1. Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development
2. Organic Chemistry Division, National Chemical Laboratory
3. Centre for Nanomedicine and Biophysical Drug Delivery, Department of Pharmaceutical Technology and Raw Material Development, National Institute for Pharmaceutical Research and Development
- Publication Type:Journal Article
- Keywords:
Malaria;
Medicinal plant;
Plasmodium falciparum
- From:Asian Pacific Journal of Tropical Biomedicine
2014;4(9):707-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the antiplasmodial properties of fractions of chloroform portion of Phyllanthus niruri (P. niruri) methanol extract and identify a suitable chemical marker present therein. Methods: Chloroform portion of P. niruri methanol extract was separated from silica gel using gradient systems of hexane, ethylacetate and methanol. The fractions were screened for antiplasmodial activity against Plasmodium falciparum HB3 and FcM29. Fractions with IC
