Serum inflammatory factor and cytokines in AECOPD
10.1016/S1995-7645(14)60177-2
- Author:
Tie-Gang JIA
1
;
Jian-Qing ZHAO
1
;
Jian-Hua LIU
1
Author Information
1. Department of Respiratory Medicine, First Affiliated Hospital of Hebei North University
- Publication Type:Journal Article
- Keywords:
AECOPD;
AHTMA;
CRP;
IL-32;
MMP-9;
PCT;
PF;
Serum
- From:
Asian Pacific Journal of Tropical Medicine
2014;7(12):1005-1008
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the serum levels of IL-32, MMP-9,PCT and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 50 patients with AECOPD and 45 cases with acute asthma attack admitted from October 2013 to August 2014 were selected, and the serum levels of IL-32, MMP-9, PCT and CRP were determined and compaed by using Double antibody sandwich Enzyme linked immunosorbent assay, immunofluorescence double antibody sandwich assay and immunoturbidimetry assay. Results: Serum levels of IL-32, MMP-9, PCT and CRP were significantly higher in AECOPD group than acute asthma attack group (. P<0.05). IL-32 and MMP-9 were negatively correlated with lung function. MMP-9 in AECOPD patients was increased more significantly. Conclusions: Serum levels of IL-32 and MMP-9 were negatively correlated with lung function, and the worse the lung function is, the more significant the increase is.
