Antioxidant lipoxygenase inhibitors from the leaf extracts of Simmondsia chinensis
10.1016/S1995-7645(14)60284-4
- Author:
Wael Mostafa ABDEL-MAGEED
1
;
Wael Mostafa ABDEL-MAGEED
2
;
Soad Abdel Latief Hassan BAYOUMI
2
;
Hanaa Mohamed SAYED
2
;
Awwad Abdoh Radwan SALAMA
3
;
Mounir Mohamed SALEM-BEKHIT
4
;
Sherif Hussein ABD-ALRAHMAN
5
Author Information
1. Pharmacognosy Department, College of Pharmacy, King Saud University
2. Pharmacognosy Department, Faculty of Pharmacy, Assiut University
3. Pharmaceutical Technology Centre, College of Pharmacy, King Saud University
4. Department of Pharmaceutics, College of Pharmacy, King Saud University
5. Biochemistry Department, College of Science, King Saud University
- Publication Type:Journal Article
- Keywords:
Antioxidant;
Flavonoids;
Jojoba;
Lignans;
Lipoxygenase inhibitors;
Simmondsia chinensis
- From:
Asian Pacific Journal of Tropical Medicine
2014;7(S1):S521-S526
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To isolate and identify chemical constituents with antioxidant and lipoxygenase inhibitory effects of the ethanolic extract of Simmondsia chinensis (Jojoba) leaves. Methods: The alcoholic extract was subjected to successive solvent fractionation. The antioxidant active fractions (chloroform, ethyl acetate and aqueous fractions) were subjected to a combination of different chromatographic techniques guided by the antioxidant assay with DPPH. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The antioxidant activity was assessed quantitively using DPPH and β-carotene methods. The inhibitory potential against enzyme lipoxygenase was assessed on soybean lipoxygenase enzyme. Results: Ten flavonoids and four lignans were isolated. Flavonoid aglycones showed stronger antioxidant and lipoxygenase inhibitory effects than their glycosides. Lignoid glycosides showed moderate to weak antioxidant and lipoxygenase inhibitory effects. Conclusions: A total of 14 compounds were isolated and identified from Simmondsia chinensis; 12 of them were isolated for the first time. This is the first report that highlights deeply on the phenolic content of jojoba and their potential biological activities and shows the importance of this plant as a good source of phenolics in particular the flavonoid content.
