Antiviral activity of maca (Lepidium meyenii) against human influenza virus
10.1016/S1995-7645(14)60268-6
- Author:
Juana DEL VALLE MENDOZA
1
;
Luis J. DEL VALLE
1
;
Tomàs PUMAROLA
2
;
Libertad Alzamora GONZALES
3
;
Luis J. DEL VALLE
4
Author Information
1. Centro de Investigación de la Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas-UPC
2. Servei de Microbiologia, Hospital Vall d'Hebron
3. Departamento Acadómico de Microbiologóa y Parasitologóa, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos (UNMSM)
4. Centre de Biotecnologia Molecular (CEBIM), Departament d'Enginyeria Quómica, ETSEIB, Universitat Politècnica de Catalunya (UPC) Barcelona Tech
- Publication Type:Journal Article
- Keywords:
Antiviral activity;
Flu;
Influenza virus;
Lepidium meyenii;
Maca
- From:
Asian Pacific Journal of Tropical Medicine
2014;7(S1):S415-S420
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively). Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK cells using method MTT assay. Antiviral activity of compounds against Flu-A and Flu-B viruses was assayed using a test for determining the inhibition of the cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC
