An update on prodrugs from natural products
10.1016/S1995-7645(14)60203-0
- Author:
Devarajan SARAVANAN
1
;
Balasubramanian KUMAR
1
;
Annamalai JAYAKUMAR
1
;
Sekar Vinoth KUMAR
2
Author Information
1. Ratnam Institute of Pharmacy Pidathapolur
2. Gokula Krishna College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Natural products;
Pharmacology;
Prodrugs
- From:
Asian Pacific Journal of Tropical Medicine
2014;7(S1):S54-S59
- CountryChina
- Language:Chinese
-
Abstract:
A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass metabolism, resulting in drug inactivation and the generation of toxic metabolites in body. Enormous numbers of prodrugs naturally present in plants, microorganism, animal and marine sources and those prodrugs undergoes chemical reaction to form non-toxic compounds. This review summarizes the list of prodrugs naturally present in the natural product.
