Expression of serum Dickkopf-1 in gastric cancer patients
10.1016/j.apjtm.2015.09.016
- Author:
Gui-Feng ZHUANG
1
;
Yan TAN
1
;
Jun-Tao ZENG
1
;
Jie-Wei ZHANG
1
;
Jing TANG
1
;
Shi-Ping ZENG
1
;
Xi QIN
2
Author Information
1. Department of Gastroenterology, Affiliated Hospital of Hainan Medical University
2. Department of Clinical Laboratory, Affiliated Hospital of Hainan Medical University
- Publication Type:Journal Article
- Keywords:
Dickkopf-1;
ELISA;
Gastric cancer
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(10):870-872
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expression and clinical significance of DKK-1 protein in patients with gastric cancers. Methods: Enzyme linked immuno sorbent assay was used to detect expressions of serum DKK-1 protein in 90 cases of gastric cancers, 50 cases of gastric benign disease and 40 healthy cases. The dynamic change in serum DKK-1 protein of gastric cancer patients who accepted radical operation for a month was also observed. Results: The expression of serum DKK-1 protein in gastric cancer groups was significantly higher than that in gastric benign group's (P < 0.01) and in health control (P < 0.01). Serum DKK-1 level was increased gradually along with the progress of the disease. Serum DKK-1 levels were significantly higher in patients at TNM staging III and IV than patients at TNM staging I and II. Level of serum DKK-1 was related to microvascular invasion, differentiation degree and infiltration depth. Level of serum DKK-1 was significantly reduced in patients after radical surgery (P < 0.01). Conclusions: The expression of serum DKK-1 protein in gastric cancer patients is increased. Level of serum DKK-1 is related to TNM staging, microvascular invasion, differentiation degree and infiltration depth. DKK-1 detection can be used as a reference index in monitoring gastric cancer progress and biological behavior.
