Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis
10.1016/j.apjtm.2015.07.019
- Author:
Monia DEGHRIGUE
1
;
Abderrahman BOURAOUI
1
;
Carmen FESTA
2
;
Maria Valeria D'AURIA
2
;
Simona DE MARINO
2
;
Lotfi GHRIBI
3
;
Hichem BEN JANNET
3
Author Information
1. Laboratoire de developpement chimique, galenique et pharmacologique des medicaments (LR12ES09), Equipe de Pharmacologie marine, Faculté de pharmacie de Monastir, Université de Monastir
2. Department of Pharmacy, University of Naples 'Federico II'
3. Laboratoire de chimie hétérocyclique, produits naturels et réactivité, Equipe de chimie médicinale et produits naturels (LR11ES39), Faculté des sciences de Monastir, Université de Monastir
- Publication Type:Journal Article
- Keywords:
Analgesic activity;
Anti-inflammatory activity;
Diterpenoid;
Eunicella singularis;
Gastroprotective effect;
Sterols
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(8):606-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions (ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/EtOH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-EtOH showed an important anti-inflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.