Effect of Yupingfeng granules on HA and Foxp3+ Treg expression in patients with nasopharyngeal carcinoma
10.1016/j.apjtm.2015.07.005
- Author:
Ji-Hong HUANG
1
;
Zhong-Lin MU
1
;
Xue-Jun ZHOU
1
;
Qiong-Lian HUANG
1
;
Feng GAO
1
;
Xi CHEN
1
Author Information
1. Hainan Medical University
- Publication Type:Journal Article
- Keywords:
Foxp3 Treg;
HA;
Nasopharyngeal carcinoma;
Yupingfeng
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(8):674-676
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Yupingfeng on hyaluronic acid (HA) and Foxp3+ Treg in patients with nasopharyngeal carcinoma. Methods: A total of 58 cases of nasopharyngeal carcinoma were divided into two groups, 30 cases in the treatment group, 28 cases in the control group. Patients in two groups were treated with synchronous radiotherapy and chemotherapy treatment, the treatment group was treated with the Yupingfeng granules through oral administration, 10 g/time, tid for 2 courses. The serum Foxp3+ Treg markers of each group were detected by flow cytometry assay before treatment and after treatment, and the level of HA in serum was detected by radio immunoassay. Results: After radiotherapy and chemotherapy, the contents of Foxp3+ Treg and HA were significantly decreased in two groups (P < 0.05), and the decrease of treatment group was more significantly (P < 0.01). Correlation analysis showed positive correlation between Foxp3+ Treg and HA (P < 0.05). After treatment, the incidence of side effects in two groups was significantly decreased. And there was significant difference between two groups (P < 0.05). Conclusions: Combined chemotherapy and radiotherapy with Yupingfeng treatment can decrease the levels of Foxp3+ Treg and HA in nasopharyngeal carcinoma patients. Yupingfeng can also effectively reduce the side effect due to radiation and chemotherapy.
